University of Newcastle upon Tyne
University of Newcastle upon Tyne belongs to the top 20 universities in the United Kingdom. It is liaised with the Newcastle upon Tyne NHS Foundation Trust, and with the establishment of the Great North Children’s Hospital has immensely strengthened local, regional and national/international excellence both in delivering “cutting edge” clinical care as well as in research, teaching and innovation for our young patients. It hosts a large PICU and general Paediatric ward. The Department of Paediatric Immunology with a large clinical and research facility is a referral centre for diagnostics and management for primary immunodeficiencies for Europe.
The team in the University of Newcastle upon Tyne and the Children’s Hospital has a long lasting experience in studying severe infectious and inflammatory diseases. Both clinical leads have conducted a PhD thesis on meningococcal disease. These theses have focussed on the role of the immune system and coagulation and fibrinolysis in meningococcal disease. Not only genetic association studies but also RNA expression profiling and protein analysis have been performed and numerous papers have been published in leading journals. The logistics have been set up within an LCRN to efficiently include patients and process samples. The team is used to closely collaborate with other successful teams.